Sunday, 8th December The 13th International Congress of the Immunology of Diabetes Society 2013

• Immune Intervention Trials – Where Are We? - Jay Skyler

• Immune-directed therapies for T1D: The ITN experience - Mario Ehlers
• Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: metabolic and mechanistic outcomes from the START trial - Stephen E Gitelman
• Immune monitoring and stratification in Type 1 Diabetes therapeutic trials - Mark Peakman

• ATG and GCSF, Combination Therapy for Type 1 Diabetes: Novel Mechanisms? - Desmond Schatz

• What contemporary clinical trial data can be used in the design of the next generation of studies? - Carla Greenbaum
• Inter-organ cross talk in the regulation of beta cell growth. - Rohit Kulkarni

Lunch will be held in Exhibition Hall

• Autoimmunity in type 1 diabetes in Indians-does it differ from other Caucasians? - Eesh Bhatia
• High Level Genetic Interactions Define Different Disease Subtypes of Type 1 Diabetes - Grant Morahan
• Non-HLA SNPs predicting early childhood auto-antibodies and diabetes: Teddy Study - Carina Torn
• Lymphocyte changes during alefacept treatment in newly diagnosed Type 1 diabetes - Mark R Rigby
• Dense genotyping of autoimmune regions identifies 3 novel T1D risk loci as well as causative genes and variants at previously reported sites. - Pat Concannon

• Lessons from nPOD - Redefining the Natural History and Pathogenesis of Human Type 1 Diabetes - Mark A Atkinson
• Proinsulin specific CD4⁺ T cells infiltrate the islets in type 1 diabetes. - Stuart Mannering
• T cell receptor analysis as a useful tool to understand the pathogenesis of type 1 diabetes - Maki Nakayama
• Pancreatic pathology at the diagnosis of human type 1 diabetes. Results from the DiViD-study. - Lars Krogvold

Maria Craig

Numbered abstracts 64 – 134

• Peripheral blood inflammatory autoimmune phenotypes indicate immunological heterogeneity in type 1 diabetes and high risk unaffected siblings - Sefina Arif
• T-cell autoreactivity at onset of pediatric Type 1 Diabetes (T1D) is related to adiposity but not autoantibodies nor c-peptide - Dorothy J Becker
• CD4⁺Tm cells in children with T1D and their siblings show increased sensitivity to activation induced cell death - Michael L Bian
• Superoxide Production Mediates Anti-Viral Responses to Diabetogenic Viruses - Ashley R Burg
• Insulitis in type 1 diabetes - Martha Campbell-Thompson
•   Assessing insulin-specific T-cell tolerance in the NOD mouse model tolerant to proinsulin - Jonathan Chee
•   Effector-Memory T-Cells develop in islets and report islet pathology in Type 1 diabetes - Jonathan Chee
• An Integrated Approach to Determine ZnT8-specific T Cell Repertoire in Type 1 Diabetes Patients and Healthy Adults - Daisuke Chujo
• Expression of innate immunity genes and damage of primary human pancreatic islets by epidemic strains of echovirus: Implication for post-virus islet autoimmunity. - Corrado M M Cilio
• Association of FOXP3 Polymorphisms with GAD65 Autoantibodies in Type 1 Diabetes  - Corrado M Cilio
• Temporal changes in cytokine expression following coxsackievirus infection of human islets - Maria Craig
• Avidity-dependent programing of autoreactive T cells in type 1 diabetes - Ivana Durinovic-Bello
• Investigating the relevance of enterovirus-specific CD8 T cell immunity in Type 1 diabetes - Martin Eichmann
• Late detection of latent autoimmune diabetes in adults associated with lower GAD antibody concentration - Spiros Fourlanos
• Low expression level of Peripheral CD4+PD-1+T-cells in Japanese Patients with Type 1A Diabetes - Reiko Fujisawa
• Latent Autoimmune Diabetes of Adults (LADA): Islet-related Autoimmunity Identifies a Unique Pattern of Impaired Beta -Cell Function and Pathology. - Roberto Gianani
• Beta cell mass in islet autoantibodies positive organ donors. - Roberto Gianani
• Increased Th22 cells are independently associated with Th17 cells in type 1 diabetes - Yong Gu
• Efficient mail-based sampling for Type 1 diabetes (T1D) autoantibody surveillance - William Hagopian
• Genetic control of regulatory T cell function in Type 1 diabetes - Emma E Hamilton-Williams
• Rapid assays for detection of type 1 diabetes associated autoantibodies in organ donors - Taina Härkönen
•   Rotavirus infection causes pancreatic apoptosis, ß-cell dysfunction and transient hyperglycemia - Margo C Honeyman
• Interferon-gamma expressing Th17 cells appear late in the development of Type 1 Diabetes - Jarno Honkanen
• Coxsackievirus B1 is associated with type 1 diabetes – results from virus antibody survey in different European populations - Heikki Hyoty
• Variable associations of non-HLA risk loci with different phases of the autoimmune process in type 1 diabetes - Jorma Ilonen
• Novel Enzyme-Linked Immunosorbent Assay for Bivalent ZnT8 Autoantibodies - Eiji Kawasaki
• A Simple Dipstick Assay Based on Lateral Flow Separation for the detection of islet antigen 2 (IA-2) autoantibodies in human serum samples - Ingrid Kikkas
• Effects of dietary gluten on murine Natural Killer cell activity  - Jesper Larsen
• Preclinical evaluation of efficacy and safety of a new vaccine against Coxsackievirus B1 – Implications for type 1 diabetes development - Pär Larsson
• Gestational infections affects birth weight differently in smoking and non-smoking mothers: The Environmental Determinants of Diabetes in the Young (TEDDY) study. - Åke Lernmark
• Elevation of serum levels of transglutaminase antibody in patients with autoimmune thyroid diseases and autoimmune diabetes - Yu Liu
• Clinical Trial of Ustekinumab for the treatment of T1D. - Ashish K Marwaha
• Ljungan virus antibody validation and relation to islet autoantibodies in autoimmune ( type 1) diabetes patients and controls. - Anna-Lena Nilsson
• Early infant feeding and islet autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study - Jill M. Norris
• Vitamin D Metabolism Genes Associated with Development of Early Childhood Islet Autoimmunity and Diabetes:  The TEDDY Study  - Jill M. Norris
• A search for susceptibility genes contributing to islet-specific autoimmunity in type 1 diabetes by association studies with multiple autoimmune diseases - Shinsuke Noso
• A lower frequency of insulin peptide B9-23-reactive IL-10-producing cells observed in type 1 diabetic patients with HLA-DRB1*09:01. - Yoichi Oikawa
• Ablation of reactive oxygen species intensifies diabetogenic CD4 T cell effector responses - Lindsey E Padgett
• Rhesus monkey rotavirus outer capsid protein VP7 confers on a bovine rotavirus the ability to replicate more efficiently in mice, elevate rotavirus-specific T helper 1-biased antibody responses and accelerate diabetes onset - Jessica A Pane
• TCR repertoire and antigen-specificity of human islet-infiltrating CD8⁺ T cells - Vimukthi Pathiraja
• Analysis of the repertoire of insulin-reactive CD8⁺ T cells - James A Pearson
• Non-synonymous Single Nucleotide Polymorphisms (SNPs) in the IA-2 Gene and Novel Epitopes within the IA-2 Extracellular Domain - Massimo Pietropaolo
• Inhibition of NADPH-oxidase (NOX) derived superoxide in T cells maintains Sirtuin-1 (Sirt-1) activity, oxidative phosphorylation, and T cell hyporesponsiveness. - Jon D. Piganelli
• Systematic Evaluation Of Genes Associated With Type 1 Diabetes Susceptibility - Ramesh Ram
• Soluble CD52 suppresses innate immune responses and is a candidate therapeutic agent in type 1 diabetes - Maryam Rashidi
• Spatial distribution of islet-associated leukocytes and beta cell nitrosative stress as contributors to beta cell loss in type 1 diabetes: studies in a cohort of nPOD cases - SHIVA REDDY
• Homozygosity of the HLA-DRB1*03,DQB1*0201 or DRB1*04,DQB1*0302 haplotypes increases the metabolic severity of T1D onset. - Arleta Rewers
• Increased weight or height gain in infants/toddlers does not predict early development of T1D: The Environmental Determinants of Diabetes in the Young (TEDDY) Study  - Marian Rewers
• CD8 infiltration of the exocrine pancreas is a common pathological feature of human type 1 and type 2 diabetes - Teresa Rodriguez-Calvo
• MHC-I hyperexpression correlates with the presence of the enteroviral capsid protein VP1 both in the islets and in the exocrine pancreas. - Teresa Rodriguez-Calvo
• Characterization of insulin specific autoreactive CD8+ T cells in autoimmune diabetes - NARESH SACHDEVA
• IL-10 receptor and endoplasmic reticulum stress impairs STAT3 activation in type 1 diabetes patients and their healthy first degree relatives - Mamdouh Sedhom
• Higher frequency of CD25-CD4+ cells observed in type 1 diabetes with HLA A*24:01 - Akira Shimada
• Role of IL-22 producing Th17 cells in Type 1 diabetes - Bhagirath Singh
• NPY minor autoantibodies in newly diagnosed type 1 diabetes patients. - Hanna Skärstrand
• Epitope specificity and affinity determined with recombinant ZnT8-aa275-369 variant proteins in specific ZnT8R and ZnT8W autoantibody positive type 1 diabetes patients  - Hanna Skärstrand
• Novel Insights into the Molecular Mechanisms by which Enteroviruses Impair Insulin-Secretion  - Emma Svedin
• Islet Antibody Remission and Risk of Type 1 diabetes in Very Young Patients in the TEDDY Study - Kendra Vehik
• The Six-year Incidence of Diabetes Associated Autoantibodies in the Genetically At-risk: The TEDDY Study - Kendra Vehik
• Th1/Th2/Th17/Treg cytokines expression levels in the peripheral blood of type 1 and type 2 diabetes patients - JIAN WANG
• Changes in zinc transporter 8 autoantibodies post onset: Studies from the Type I Diabetes Genetics Consortium. - Janet M Wenzlau
• Proliferating germinal centres are decreased in recent onset type 1 diabetes pancreatic lymph nodes - Abby Willcox
• Autoantibodies to GAD(96-585) identify GAD autoantibody positive relatives of patients with type 1 diabetes at increased risk of diabetes progression - Alistair JK Williams
• The important role of MyD88 in dendritic cells in obesity and metabolic syndrome - Yufei Xiang
• Inhibition of increased circulating Tfh cell by anti-CD20 monoclonal antibody in patients with type 1 diabetes - Xinyu Xu
• T cells specific for Insulin B:11-23 restricted on HLA-DQ8 are frequently detected in T1D patients and primarily recognize Register 3 as the immunogenic peptide binding mode on DQ8 - Junbao Yang
• A negative association between HLA-A*24 and islet autoantibody responses in pre-diabetes - Jody Ye
• Higher prediction values of ECL-IAA and -GADA assays for type 1 diabetes - Liping Yu
• Low prevalence of GAD and IA2 antibodies in Indian patients with type 2 diabetes: a clinic and community based study - Eesh Bhatia