Transglutaminase
antibody (TGA) is specific for celiac
disease(CD).
Some studies have shown that CD is associated
with autoimmune thyroid
diseases (AITD) and autoimmune type 1 diabetes (T1DM). T1DM, AITD and CD are components
of autoimmune polyendocine syndrome(APS) type Ⅱ.We investigated
the relationships among T1DM, AITD and CD by detecting the titers of TGA, glutamic acid decarboxylase antibody (GADA), insulinoma
associated protein-2 antibody (IA-2A), zinc transporter 8 antibody (ZnT8A) and
TSH receptor antibody (TRAb). TGA
level in T1DM group and AITD group is significantly higher than that in type 2
diabetes (p<0.01) and non-autoimmune thyroid diseases (NAITD)(p<0.01), respectively. Positive rate of GADA,IA-2A and ZnT8A in patients with T1DM was 34.52%(29/84),
25.00%(21/84) and 38.10%(32/84), respectively, higher than that in T2DM group (p<0.001).In AITD group, the occurrence rate of CD (p<0.05) and positive rate of any islet autoantibody (p<0.05) in patients with positive TGA was higher than that
of TGA negative patients. In addition, there was a positive correlation (r=0.567, p<0.01) between TGA and TRAb. TGA positive patients had
lower body mass indexes (p<0.05) than TGA negative patients but the rate of any
islet autoantibody and age had no significant difference in T1DM group. In
conclusion, serum level of TGA in patients with AITD and T1DM was elevated.
Detection of TGA in patients with autoimmune diseases was very important for
the early diagnosis and prevention of APS.