Monday, 9th December The 13th International Congress of the Immunology of Diabetes Society 2013

The Network for Pancreatic Organ Donors with Diabetes (nPOD) program is a JDRF funded initiative to provide investigators with rare and difficult to obtain human tissues to study type 1 diabetes (T1D) from deceased individuals at varying stages at disease development.  Initiated in 2007, nPOD currently supports over 100 basic science research projects worldwide ranging in areas from disease pathogenesis and etiology to novel biomarkers, immunology, and beta cell development, differentiation, regeneration, physiology, and dysfunction.  Several new nPOD initiatives are being forged with collaborators in and outside of the US to share knowledge, tissue, and data in efforts to expedite our understanding of T1D.   For example, nPOD is developing DataShare, a web-enabled tool for collaboration organized around the nPOD specimen repository.  DataShare  is a program that investigators can use to obtain detailed information about donors in the nPOD collection, as well as share their findings and make connections with other researchers who are studying the same samples.  This breakfast session will introduce and provide the latest updates on the nPOD program.

• Understanding the histopathology of human type 1 diabetes to develop improved therapeutic approaches - Matthias von Herrath

• Reversal of early-onset autoimmune diabetes by TLR2 tolerization in conjunction with dipeptidyl peptidase 4 inhibition - Myung-Shik Lee
• The effect of microbiome/Toll-like receptor interactions on susceptibility to type 1 diabetes - Alan G Baxter
• Innate immune responses and type 1 diabetes:  A role for a long non-coding RNA? - Tom Brodnicki
• Vitamin D: What else? - Chantal Mathieu
• Cross-Talk between Toll-Like Receptors and the Intestinal Microbiome in Diabetes Induced with a Mimic of Viral Double-Stranded RNA - Danny Zipris

• Febrile respiratory infections are associated with increased risk of islet autoimmunity in the TEDDY study - Heikki Hyoty
• Can a vaccine protect from enterovirus infection and type 1 diabetes development? - Malin Flodström Tullberg
• The JDRF nPOD-Virus Group - Alberto Pugliese
• Enteroviral infection in human type 1 diabetes: correlative evidence from multiple sources in nPOD samples - Sarah Richardson
• Rotavirus acceleration of murine type 1 diabetes is associated with pro-inflammatory cytokine expression by T cells and increased antigen presentation by B cells - Barbara S Coulson

• Impact of Type 1 Interferons on Human ß Cells - Clayton Matthews
• Activation of innate immunity and type 1 interferon production in initiation of diabetes in non-obese diabetic mice - Helen Thomas
• E2-2 dependent plasmacytoid dendritic cells promote diabetes - Lisbeth Hansen
• CD8+ T-cells in Type 1 diabetes: Revealing the culprits - Ania Skowera

• Manipulating beta cells for local modulation of autoimmunity: taking a page from the tumour playbook - C.Bruce Verchere
• Lysine deacetylases as therapeutic targets in type 1 diabetes mellitus. - Thomas Mandrup-Poulsen
• Network analysis identifies cytokine signaling pathways involved in genetic risk common to autoimmune diseases - Stephen S Rich
• Endogenous IL-22 is an Intrinsic Suppressor of β-cell ER Stress and Islet Inflammation and Exogenous IL-22 Restores Glycaemic Control in Obesity - Michael McGuckin

Numbered abstracts 135 – 205

• Diab-Q-Kit II: Next generation combinatorial nanotechnology for profiling islet autoreactive CD8 T-cells for immune memory and activation - Joana Abreu
• Haploinsufficiency of Interferon regulatory factor 4 strongly protects from autoimmune diabetes in the non-obese diabetic mice - Satoru Akazawa
• Serum miRNA profile in children with high risk for type 1 diabetes - Linda Åkerman
• Functional Modification of Epidermal Dendritic Cells by Topical Steroids to optimize Tolerogenic Potential of Immunotherapy for Type 1 Diabetes - Mohammad Alhadj Ali
• Investigation of  Slc16a10’s role in immune cell function and autoimmune diabetes - May Alsayb
• T-cell regulation by a trimolecular complex of CD52, HMGB1 and Siglec-10 - Esther Bandala-Sanchez
• MicroRNA profiling of impaired CD4⁺ T regulatory cells residing in the pancreatic draining lymph-nodes of patients with type 1 diabetes - Manuela Battaglia
• Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model - Jamie L Brady
• Allergy to self: the role of mast cell in the pathogenesis of diabetes - Corrado M Cilio
• Proteomic profiling of antigenic beta cell extracts. - Thomas Delong
• Peptide elution to identify preproinsulin epitopes from T1D risk-associated MHC class I variants - Martin Eichmann
• The interplay between transplant tolerance to pancreatic islets and acute anti-viral immune responses - Georgia Fousteri
• Identification of CD8⁺ T cell targets in the major T1D autoantigen IA-2beta - Yannick F Fuchs
• Vaccination with tolerogenic dendritic cells impedes autoantigen-specific inflammatory response in vivo - Vivienne Gibson
• Thymic B cells; new players in T1D progression? - Allison Green
• Reversing New-Onset Diabetes in NOD mice by Combining Sitagliptin with GW9508, a GPR40 and GPR120 Dual Agonist - Zhiguang Guo
• Analysis of immune, metabolic and clinical biomarkers implicates inflammatory and stress pathways in the pre-clinical development of type 1 diabetes - Mark Harris
• Aspartame lowers the fasting blood glucose, but not the diabetes incidence, in NOD mice fed a gluten-free diet  - Martin Haupt-Jorgensen
• Preclinical xenotransplantation of genetically altered porcine neonatal islet cell clusters that express human CD55 and CD59 and Gal KO prevent thrombosis are a step closer to cure type 1 diabetes. - Wayne J Hawthorne
• On the road to unraveling the mechanistic pathways of the Instant Blood Mediated Inflammatory Reaction against Porcine Neonatal Islet Cells. - Wayne J Hawthorne
• Imaging the dynamics of progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes - Dan Holmberg
• Low Dose of Rapamycin/IL-2 Treatment Protect Human Islet Allograft from Rejection in a Humanized Diabetic Mouse Model - Min Hu
• Increased Recognition of Post-translationally Modified Epitopes in Subjects with Type 1 Diabetes - Eddie A James
• Immune-suppressive Properties of Human Islet-derived Progenitor Cells - Mugdha Joglekar
• Doubly reactive autoantibodies define INS-IGF2 as an autoantigen largely in HLA-DQ2/8 patients newly diagnosed with autoimmune (type 1) diabetes. - Norio Kanatsuna
• The type 1 diabetes-associated gene CLEC16A modulates thymic epithelial cell function and impacts T cell reactivity - Stephan Kissler
• Mapping of epitopes of autoantigen IA-2 based on computational analysis - Yu Liu
• Broad activation of the IL-2R gene program in human T regulatory cells is selectively supported by low-dose IL-2 - Thomas R Malek
•   The serine protease granzyme A controls activation of innate immunity and type 1 interferon production in non-obese diabetic mice - Zia Mollah
• Natural Killer Cell Function and Phenotype in NOD and NOD-Alox15^null Mice - Margaret A. Morris
• Glucagon-Like Peptide-1 protects human islets against cytokine-mediated beta-cell dysfunction and death: a proteomic study of the pathways involved. - Lut Overbergh
• Molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and mouse islets of Langerhans. - Lut Overbergh
• Gene expression in peripheral blood of pre-diabetic NOD mice predicts onset of type 1 diabetes and identifies new clinical biomarkers - Dimeng Pang
• The immunosuppressive and protective ability of glucose-regulated protein 78 (GRP78) and Bax inhibitor 1 (BI-1) for improvement of alloimmunity in ß cell transplantation - Yongsoo Park
• Antidiabetic and antioxidant activities of saponin fraction of Eranthemum roseum in streptozotocin-induced diabetic rats - Sachin Patil
• The Emerging Role of Regulatory B Cells in Type 1 Diabetes - Massimo Pietropaolo
• Short Course Oral Therapy with Plant-Derived Autoantigens Delays Type 1 Diabetes Onset in NOD Mice. - Amanda Posgai
• Serum microRNA profiling in type 1 diabetes - Alberto Pugliese
• Treatment of Recurrent Islet Autoimmunity in a Pancreas Transplant Recipient with Alefacept - Alberto Pugliese
• Deficiency in type I interferon signaling prevents the early interferon-gene signature in pancreatic islets but not type 1 diabetes in non-obese diabetic mice. - Hong Sheng Quah
• Characterization of the healthy interaction between the human immune cells and the pancreatic islet - Miljana Radenkovic
• Peripheral tolerance induction in insulin-specific CD8⁺ T cells - Peta Reeves
• Effect of Gelam honey on the oxidative stress induced signaling pathways in pancreatic hamster cells - Sher Zaman Safi
• Nardilysin-dependent proteolysis of cell-associated VTCN1(B7-H4): A novel pathway and biomarker in the development of type 1 diabetes - Alexei Savinov
• The role of IFNγ-induced expression of MHC class II by endothelial cells in efficient T cell homing to pancreatic islets - Nicholas A Scott
• Heparan sulfate (HS) deficiency in isolated islets is due to oxidative damage and not heparanase (Hpse)-mediated degradation - Charmaine Simeonovic
• Heparan sulfate (HS) status of human islet beta cells is a sensitive marker of beta cell integrity - Charmaine Simeonovic
• Functional impairment and phenotypic shift of natural and induced regulatory T cell in early development of Type 1 Diabetes in an experimental model - Kailash Singh
• IL-23 receptor signalling promotes pathogenic T cell responses and type 1 diabetes in NOD mice  - Andrew PR Sutherland
• Lymph node fine needle aspiration biopsy, a minimally invasive monitoring technique of antigen-specific immune responses in humans - Danijela Tatovic
• Lack of suppressive capacity of CD4⁺CD25⁺CD127^lowFOXP3⁺ regulatory T cells in IL-15 rich environments - Anke Theil
• Perforin regulates naïve T cell responses and kills beta cells in type 1 diabetes in non-obese diabetic mice - Prerak Trivedi
• Superoxide-Deficient Non-Obese Diabetic Macrophages Exhibit An M2 Phenotype - Hubert M Tse
• Circulating microRNA-375, a potential biomarker for beta-cell death in T1D? - Tina Uvebrant
• Oral delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice - Tom Van Belle
• 1,25-dihydroxyvitamin D3 and its Analogue TX527 Promote a Regulatory T Cell Phenotype in T Cells from Type 1 Diabetic Patients - Tom Van Belle
• Identification of unique T1D and T2D sub-groups using unsupervised clustering of longitudinal immune biomarker data - Johnna D Wesley
• Catenarin, an anthraquinone compound, inhibits CXCR4 and CCR5 pathways to protect against type 1 diabetes in NOD mice - Wen-Chin Yang
• Slow progression to type 1 diabetes - Yi Ye
• Diminished Adenosine A1 receptor expression in pancreatic alpha cells may contribute to the pathology of Type 1 Diabetes - Linda Yip
• Inflammation and hyperglycemia induce the splicing of Deaf1 in the pancreatic lymph nodes during the progression of Type 1 diabetes - Linda Yip
• A Novel Hydrogel Microparticle Matrix to Deliver Autoantigen and Adjuvant utilizing the NOD mouse to prevent Type 1 Diabetes. - Young-Mee Yoon
• Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells - Yuxia Zhang
• Neocrotic death of pancreatic beta cells in type 1 diabetes - Yuxing Zhao
• Saraca indica fraction prevents cataract development and progression in streptozotocin-induced diabetic rats - Gauresh somani