Todd M Brusko
Dr. Todd Brusko appointed as a Professor in the Department of Pathology at the University of Florida. He currently serves as the Assistant Dean of Basic Research for the College of Medicine and the Director of the UF Diabetes Institute.
The research interests of the Brusko Laboratory are centrally themed around understanding the mechanisms by which the immune system maintains a state of control, often referred to as immunological tolerance. This includes studies of the immune system, with a particular focus on understanding what goes wrong in individuals that develop autoimmune diseases, including a primary focus on type 1 diabetes (T1D). Dr. Brusko has been involved in foundational research and development efforts to bring a number of novel therapies from the bench to the bedside in first in human clinical trials. Dr. Brusko has published over 165 studies reporting cellular immune defects in patients with autoimmune diseases and investigated cellular immune mechanisms and biological basis of such diseases. A major goal of the Brusko Laboratory is to create a basic understanding of immune system development over the human lifespan in peripheral blood and within central and peripheral immune tissues. These efforts are enabled through precision medicine genotyping and molecular profiling using cutting-edge technologies in spatial biology. Collectively, these efforts provide a foundational framework for defining immunity in health and identifying defects in immune system development indicative of disease to create robust biomarkers and targeted immune interventions to restore immune regulation in T1D.
Abstracts this author is presenting: