Oral Presentation The 13th International Congress of the Immunology of Diabetes Society 2013

Pancreatic pathology at the diagnosis of human type 1 diabetes. Results from the DiViD-study. (#20)

Lars Krogvold 1
  1. Oslo University Hospital, Oslo, Norway

The cause of type 1 diabetes is still unknown, partly due to lack of studies of pancreatic tissue from patients at diagnosis. The aim of the Diabetes Virus Detection Study was to collect fresh pancreatic tissue with laparoscopic tail resection under general anaesthesia from live adult individuals with newly diagnosed type 1 diabetes. The study was approved by the Government’s Regional Ethics Committee. Pancreatic tail resection was carried out for six patients (three men, three women, 24-35 years of age) three to nine weeks (median five weeks) after the diagnosis of type 1 diabetes. The collected specimens were of excellent quality (snap-frozen at – 80 degrees less than three minutes after sampling) and obtained within an optimal time-window for the analysis of the diabetic pancreatic pathology. At IDS, different results from DiViD will be presented, including clinical data and complications among the cases, analyses regarding the presence of virus, close description of the inflammation, insulin secreting function and expression of inflammatory-related proteins in isolated islets and whole transcriptome sequencing of islets.